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HEPATITIS B

HBV is an enveloped, double-stranded DNA virus belonging to the Hepadnaviridae family and is recognized as the major cause of blood transmitted hepatitis. Classification of a HBV infection requires the identification of several serological markers expressed during the three phases (incubation, acute and convalescent) of the infection.

HBsAg: is the most important protein of the envelope of HBV. Four HBsAg subtypes have been identified (adw, ady, ayw, and ayr). HBsAg can be detected 3 to 5 weeks before the development of symptoms. The serological detection of HBsAg is a powerful method for the diagnosis and prevention of HBV infection and for screening of blood donors.

Anti-HBc is a marker of acute, chronic or resolved HBV infection.In clinical diagnosis, the detection of anti-HBc is an important marker for diagnosis and management of disease. In the absence of other HBV markers (HBsAg-negative persons), anti-HBc may be the only indication of an existing HBV infection.

HBcAb IgM: Antibodies to HBcAg are produced shortly after the appearance of HBsAg and persist for life both in persons who have recovered from a Hepatitis B infection and in those who develop HBsAg carrier status. In chronic hepatitis, however, spikes of anti-HBc IgM synthesis can be observed, confirming reactivation of HBV in hepatocytes and giving origin to permanent low titers of IgM. 

HBsAb: During the acute phase of hepatitis B infection, increasing titers of HBsAg neutralizing antibodies are a marker for recovery. The absence of anti-HBs indicates susceptibility to HBV infection. 

HBeAg: The “e” antigen is a viral protein associated with HBV replication, indicating a high degree of infectivity of the tested individual. In chronic Hepatitis B infections, elevated levels of HBeAg can be detected for years, which is a marker for a high viral load. 

HBeAb: After treatment, in the recovery phase following acute hepatitis B, HBeAg is the first serological marker that becomes negative and is replaced by the corresponding antibody (anti-Hbe). The presence of anti-HBe in blood is recognized to be a clinical sign of recovery from the infection.
 
HBV NRAg: The hepatitis B virus particle is composed of outer membrane proteins (S protein, pre-S1 protein, pre-S2 protein) and the core-shell. The HBV pre-S1 and core antigens are not only markers of HBV infection, but also of viral replication, and they are highly correlated with the amount of HBV DNA, collectively known as hepatitis B virus nucleic acid related antigen (HBV NRAg).
Catalog No.
  Products
Brochures
Certification
IFU
  WB-1296   HBsAg ELISA
CE
  WB-2396
  HBsAb ELISA
 
  WB-2496
  HBeAg ELISA
 
  WB-2596
  HBeAb ELISA
 
  WB-2696
  HBcAb ELISA
 
  WB-26S96   HBcAb ELISA (Sandwhich)    
FR
العربية
  WB-2796
  HBcAb IgM ELISA
 
  WB-2896
  HBsAb (Quantitative) ELISA
 
  WB-2996   HBV NRAg ELISA    
  WJ-11
  HBsAg Rapid Test (s/p/wb)
 
  WJ-14
  HBsAb Rapid Test (s/p/wb)
 

 

 

 

 

 

 

 

 

 

 

 

 

 



 

 

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